A child prodigy on violin and piano, Miroslav Sekera won numerous competitions on both instruments, gaining the attention of Milos Forman who cast him at the age of six as the child Mozart in the 1985 film Amadeus. Eventually, Mirek chose to concentrate on piano and in 1991 he won first prize in the Chopin Competitionat Mariánské Lázne. Other awards include first prizes in the National Competition of Czech Conservatories, the Baden Competition for Best Performance of a work by Leos Janacek, the 1999 Prague Academy of Music Arts, and the 2002 Johannes Brahms International Competition at Portschach, Austria. He has also achieved prize winning performances at the Gaillard International Piano Competition in France as well as the Nadezda-Sazinova Piano Competition. Sekera has performed solo recitals throughout the world, including Austria, Switzerland, Belgium, Holland, France, the Caribbean, and Jakarta, Indonesia.

A perennial artist with The Shakespeare Concerts, he participated in both the 2003 debut season and the inaugural 2005 recording What A Piece Of Work Is Man. In his many seasons with The Shakespeare Concerts Mirek has premiered eleven compositions by Joseph Summer, including The Dumb Show in Boston in 2004. Critic Roger Lakins, writing about Sekera in the 2003 The Shakespeare Concerts, opined that he is "an awesome talent. As both a solo performer and accompanist, he is absolutely amazing... This young performer has so much going on that is far surpassing technical brilliance. His performance of the 'Tempest Sonata' of Beethoven was a mystical experience. This listener heard new things in a work that has been a favorite most of his life. In Sekera's hands, the second movement is otherworldly. Form, line, harmony - they all disappeared. Just sheer beauty, beauty unfolding in all those ways and many more." Mirek's recording of Scarlatti piano sonatas, the Brahms piano sonata in f minor, and two bravura Moszkowski works is available under the title Augury of Amadeus.